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KMID : 1147520080010010017
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Korean Academy of Basic Medicine & Health Science
2008 Volume.1 No. 1 p.17 ~ p.22
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The Effect of Yukmijihwangtang-gamibang on the Lung Tissue Induced with PQ
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Yoon Jung-Sik
Kim Jin-Ho
Kim Jeong-Sang
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Abstract
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Based on the literature review, this study was attempted to see the beneficial effects of oriental medicine on the aging process by using the senescence accelerated mouse (SAM). Paraquat (PQ, 2×10-7 mg/kg) was administered to the four-month old senescence accelerated mouse to induce the oxidative and cellular damage. The experimental groups are administered with YukmiGa followed by PQ treatment. The lung samples were obtained after sacrificing them for electron microscopical observation. In the lung, PQ caused a hugh damage on pneumocyte type I and type II cells from cellular toxicity. In the YukmiGa treatment groups, slightly damaged cellular organelles were observed from 1 day to 6-day treatment groups. These experimental groups showed normal endothelial cells of capillary and alveolar endothelial cells. It is assumed that YulmiGa could suppress the cellular toxicity from PQ treatment in the lung. Also, YulmiGa seems good effect for its anti-aging action at in the SAM model.
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KEYWORD
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Paraquat, Yukmijihwangtang-gamibang (YukmiGa), Pneumocyte, SAM
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